Tsung-Ta Wu, MD
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Research

Three lines, all concerned with keeping patients physiologically stable through surgery.

Perioperative hemodynamics and hypotension exposure

How intraoperative hypotension should be measured (MAP thresholds, time-weighted average, area under the threshold), whether prediction algorithms such as the Hypotension Prediction Index change patient outcomes rather than just the exposure metric, and where the evidence chain from 2007 to today still has gaps. A randomized trial comparing the Hypotension Prediction Index with a high mean arterial pressure target was published in Anesthesiology in 2026.

Microcirculation and organ protection

With the NTUH Center of Microcirculation Medical Research (NCMMR): sedative choice and its effect on microcirculatory flow and organ injury, and fluid strategy in transplantation.

Hemodynamic monitoring in difficult positions and difficult physiology

Non-invasive surrogates for cardiac output: airway pressure during prone-position spine surgery; dynamic preload variables in liver cirrhosis.

Selected publications

  1. Wu T-T, Chen P-J, Tu Y-K, Wang Y-P, Tsai J-L, Chan K-C, Hsu I-L, Wu C-Y. Hypotension Prediction Index versus high mean arterial pressure target for preventing intraoperative hypotension: a randomized controlled trial. Anesthesiology. Published online 17 August 2026. doi:10.1097/ALN.0000000000006335
  2. Wang Y-P, Chen P-J, Yu H-L, Syu J-F, Wu C-Y, Wu T-T*. Airway pressure as a predictor of cardiac output reduction in prone position spine surgery: a prospective observational study. J Formos Med Assoc. 2025;124(1):56–63. doi:10.1016/j.jfma.2025.01.013
  3. Chen P-Y, Huang H-H, Chan W-S, Liu C-M, Wu T-T, Chen J-H, Chao A, Tien Y-W, Chiu C-T, Yeh Y-C*. Comparison of dexmedetomidine versus propofol sedation on microcirculation and organ injuries in critically ill surgical patients: a randomized controlled pilot study. Clin Hemorheol Microcirc. 2024;32(3):547–555. doi:10.3233/CH-232093
  4. Chang T, Shih M-C, Wu Y-L, Wu T-T, Yang J-T, Wu C-Y*. Comparative efficacy of balanced crystalloids versus 0.9% saline on delayed graft function and perioperative outcomes in kidney transplantation: a meta-analysis of randomised controlled trials. Br J Anaesth. 2024;133(2):256–265. doi:10.1016/j.bja.2024.08.008

* corresponding author. Full list on Google Scholar.